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sage decreases outcomes of diazepam by pharmacodynamic antagonism. Insignificant/Significance Not known. Theoretical conversation; some species of sage might result in convulsions.
withdrawal reactions, like seizures, which may be existence-threatening; use gradual taper when discontinuing therapy to lower withdrawal reactions threat
Incorrect or abnormal use of diazepam can lead to dependence. At a very large threat for diazepam misuse, compound use problem or dependence are:
An individual caring for it is best to search for crisis healthcare consideration When you have sluggish respiration with long pauses, blue colored lips, or Should you be hard to get up.
Someone who has eaten an excessive amount diazepam commonly shows a number of of such indicators in a duration of somewhere around 4 several hours right away pursuing a suspected overdose:[38][89]
In case you are prescribed diazepam for greater than 4 months, your dose may very well be diminished gradually if you prevent having it to avoid withdrawal symptoms.
cyclosporine will increase the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Suggest both of those patients and caregivers about dangers of respiratory despair and sedation when diazepam is used with opioids; advise patients not to travel or work heavy equipment until the consequences of concomitant use With all the opioid are already established
stiripentol will lessen the level or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Consider decreasing the dose of CYP2C19 substrates, if adverse reactions are expert when administered concomitantly with stiripentol.
voriconazole will raise the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
diazepam will improve the amount or outcome of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
If you are taking diazepam frequently and neglect to click here take a dose, take the skipped dose once you try to remember, Until It truly is just about time to your up coming dose. In this instance, just go away out the missed dose and get your next dose at the same old time.
istradefylline will raise the stage or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
in these parts, resulting in anxiolytic and antiepileptic results.five Along with its focused system, diazepam’s